Living Under the A’ Roof

Living Under the A’ Roof

Living Under the A’ Roof (#10)

Jamie Rossjohn ¹

Monash University, Clayton , VIC, Australia

T cells can recognise lipid-based antigens when presented by the CD1 family, of which there are four members of antigen-presenting molecules, CD1a-d. Each CD1 member possesses unique structural features that suggest distinct functional roles in the context of protective immunity and aberrant T cell reactivity. Moreover, each CD1 isoform presents specific challenges for T cell receptor (TCR) recognition. I shall compare and contrast TCR-CD1-lipid recognition, revealing that it can fundamentally differ from that of TCR-MHC-peptide recognition. This suggests that lipid-mediated presentation and recognition should move out of the shadow of MHC biology.

Authors contributing to this presentation.

Rossjohn, J

Prof. Rossjohn is an NHMRC Australia Fellow at Monash University. Rossjohn has provided profound insight into T-cell biology, defining the basis of key immune recognition events by T-cells. He has used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. He has unearthed mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. He has pioneered our understanding of lipid-based immunity by the innate Natural Killer T-cells, as well as MAIT cell recognition of vitamin B metabolites.

Living Under the A’ Roof (#10)

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Rossjohn, J

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